{"id":6027,"date":"2026-09-22T15:41:19","date_gmt":"2026-09-22T15:41:19","guid":{"rendered":"https:\/\/smartdryeyes.com\/?page_id=6027"},"modified":"2026-09-22T16:47:05","modified_gmt":"2026-09-22T16:47:05","slug":"lacrifill-treatment-for-dry-eyes","status":"publish","type":"page","link":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/","title":{"rendered":"Lacrifill\u00ae Treatment for Dry Eyes"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull sde-tx sde-tx--media is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"txhero\">\n<div class=\"txw\">\n<div class=\"txhero-in\">\n<div>\n<p class=\"eyebrow\">Treatment<\/p>\n<h1>Lacrifill\u00ae Treatment for Dry Eyes<\/h1>\n<p class=\"txsub\" style=\"font-family:var(--sans);font-size:clamp(15px,1.25vw,17.5px);font-weight:600;line-height:1.45;letter-spacing:.005em;margin:-6px 0 18px;max-width:46ch;color:var(--p900)\">Cross-linked hyaluronic acid gel for temporary closure of the tear drainage<\/p>\n<p class=\"txlede\">Lacrifill\u00ae is a sterile, clear gel of cross-linked hyaluronic acid. It is placed in the lower canaliculus, the tear drainage canal of the eyelid, and temporarily reduces tear outflow. As a result, the eye\u2019s own tears stay on the ocular surface for longer. The gel adapts to the canaliculus, is not visible from outside and can be rinsed out with sterile saline in the event of discomfort or complications.<\/p>\n<div class=\"txbtns\"><a class=\"txp\" href=\"https:\/\/smartdryeyes.com\/en\/start-dry-eye-treatment\/\">Start your screening<\/a><a class=\"txo\" href=\"https:\/\/smartdryeyes.com\/en\/dry-eye-treatment-options\/\">All treatment options<\/a><\/div>\n<\/div>\n<figure><img src=\"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-gel-hialuronico-hero.webp\" alt=\"Clear Lacrifill gel emerging as a fine strand from the tip of the pre-filled syringe\" fetchpriority=\"high\" decoding=\"async\" width=\"1920\" height=\"1080\" style=\"object-position:88% 50%\"><figcaption style=\"font-size:12px;line-height:1.5;color:#8FA5AB;margin-top:8px;text-align:right\">Photo: <a href=\"https:\/\/lacrifill.com\/\" rel=\"nofollow noopener\" target=\"_blank\">Nordic Pharma \u00b7 lacrifill.com<\/a> (cropped)<\/figcaption><\/figure>\n<\/div>\n<dl class=\"txglance\"><div><dt>Treatment time<\/dt><dd>A few minutes for both eyes<\/dd><\/div><div><dt>Duration in place<\/dt><dd>Up to 6 months<\/dd><\/div><div><dt>Sensation<\/dt><dd>Slight pressure; anaesthetic drops<\/dd><\/div><div><dt>Downtime<\/dt><dd>Usually none<\/dd><\/div><\/dl>\n<\/div>\n<\/div>\n\n\n\n<div class=\"txb\">\n<div class=\"txw\">\n<div class=\"txsplit\"><div><div class=\"txhead\"><span class=\"txnum\">01<\/span><span class=\"txrule\"><\/span><\/div><h2 class=\"txh\" id=\"what-lacrifill-treats\">When Lacrifill is used<\/h2><\/div><div><div class=\"txprose\"><p>Lacrifill\u00ae can be used in adults with symptoms of dry eye when reducing the tear outflow appears medically appropriate. This applies most obviously in <strong>aqueous tear deficiency<\/strong>. Signs of this include a low Schirmer value, a low tear meniscus and staining of the ocular surface.<\/p><p>The principle is the same as with punctal plugs: if less tear fluid drains away through the tear ducts, the tears that are present stay on the ocular surface for longer. Lacrifill\u00ae does <strong>not use a preformed plug for this, but a gel<\/strong> that fills the canaliculus from the inside.<\/p><p>Lacrifill\u00ae <strong>does not increase tear production<\/strong> and treats neither inflammation nor meibomian gland dysfunction. If the lipid layer is deficient or the lid margins are inflamed, these causes are therefore treated, or brought under control, first.<\/p><figure class=\"txplate\"><img src=\"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-gel-canalicular-envase.webp\" alt=\"Box and pre-filled syringe of Lacrifill canalicular gel on an instrument tray in front of a slit lamp\" loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"1067\"><figcaption>Lacrifill is supplied as a sterile pre-filled syringe containing 0.6 ml of gel; the amount is sufficient for both eyes of one patient. Image: <a href=\"https:\/\/lacrifill.co.uk\/\" rel=\"nofollow noopener\" target=\"_blank\">Nordic Pharma \u00b7 lacrifill.co.uk<\/a>.<\/figcaption><\/figure><\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"txb txb--tint\">\n<div class=\"txw\">\n<div class=\"txsplit\"><div><div class=\"txhead\"><span class=\"txnum\">02<\/span><span class=\"txrule\"><\/span><\/div><h2 class=\"txh\" id=\"how-lacrifill-works\">How Lacrifill works<\/h2><figure class=\"txchain\"><figcaption>Mechanism<\/figcaption><ol><li><span class=\"n\">01<\/span><span class=\"t\">Tears drain through the puncta into the canaliculi<\/span><\/li><li><span class=\"n\">02<\/span><span class=\"t\">The gel fills the lower canaliculus<\/span><\/li><li><span class=\"n\">03<\/span><span class=\"t\">Tear outflow is temporarily reduced<\/span><\/li><li><span class=\"n\">04<\/span><span class=\"t\">The eye\u2019s own tears stay on the ocular surface for longer<\/span><\/li><li><span class=\"n\">05<\/span><span class=\"t\">After six months at the latest, the gel is rinsed out<\/span><\/li><\/ol><\/figure><figure class=\"txplate\"><img src=\"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-esquema-canaliculo-lagrimal.webp\" alt=\"Illustration of an eye with the tear drainage system; the Lacrifill gel is shown in the lower tear canal\" loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"1240\"><figcaption>The gel (blue-violet) fills the lower tear canal at the inner corner of the eye; the tear canals, the lacrimal sac and the duct to the nose are shown in pink. Illustration: <a href=\"https:\/\/lacrifill.co.uk\/patient\/\" rel=\"nofollow noopener\" target=\"_blank\">Nordic Pharma \u00b7 lacrifill.co.uk<\/a>.<\/figcaption><\/figure><\/div><div><div class=\"txprose\"><p>Tear fluid is produced continuously, spread over the ocular surface with every blink and drained at the inner corner of the eye. There, at the edge of the upper and lower lid, lies a fine opening, the punctum. It leads into a duct about ten millimetres long, the canaliculus. The upper and lower canaliculi open into the lacrimal sac, from where the tears pass into the nose.<\/p><p>Lacrifill\u00ae consists of <strong>non-animal hyaluronic acid<\/strong> whose molecular chains are cross-linked. This produces a gel that holds its shape. It is introduced through the lower punctum with a fine lacrimal cannula and fills the canaliculus. Unlike a preformed plug, <strong>no fixed size<\/strong> has to be chosen.<\/p><p>Because less drains away, both the eye\u2019s own tear fluid and any eye drops applied can remain on the ocular surface for longer. Tear production itself does not change. As the effect of medicated eye drops may be increased, their dosage may need to be adjusted.<\/p><p>The occlusion is temporary. Lacrifill\u00ae is intended for use for <strong>up to six months<\/strong>; safety and effectiveness beyond that period have not been established. In the event of irritation, infection, persistent watering or another adverse event, the gel is rinsed out of the canaliculus <strong>with sterile saline<\/strong>.<\/p><\/div><div class=\"txcall\"><p><strong>Important note.<\/strong> Lacrifill\u00ae is a CE-marked medical device. The legal manufacturer is Nordic Group B.V. in the Netherlands. Smart Dry Eyes has no commercial relationship with the manufacturer or distributor. Tear drainage can also be reduced with silicone plugs or dissolvable plugs. Which procedure is suitable is decided by the ophthalmologist after the examination.<\/p><\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"txb\">\n<div class=\"txw\">\n<div class=\"txhead\"><span class=\"txnum\">03<\/span><span class=\"txrule\"><\/span><\/div><h2 class=\"txh\" id=\"what-a-lacrifill-treatment-involves\">What a Lacrifill\u00ae treatment involves<\/h2>\n<style>html .entry-content .sde-tx .txvisit{display:grid;grid-template-columns:minmax(0,7fr) minmax(0,5fr);gap:clamp(32px,5vw,72px);align-items:stretch;margin-top:clamp(24px,3vw,40px)}html .entry-content .sde-tx .txvisit .txsteps{margin:0}html .entry-content .sde-tx .txvisit-fig{margin:0;display:flex;flex-direction:column;min-width:0}html .entry-content .sde-tx .txvisit-fig img{display:block;width:100%;height:0;min-height:320px;flex:1 1 0;object-fit:cover;object-position:6% 50%;border-radius:24px;box-shadow:0 18px 40px -20px rgba(21,49,58,.45)}html .entry-content .sde-tx .txvisit-fig--anim img{object-position:80% 50%;max-height:600px}html .entry-content .sde-tx .txvisit-fig figcaption{font-size:11.5px;line-height:1.45;color:#8FA5AB;margin:0;padding:11px 2px 0;text-align:left}html .entry-content .sde-tx .txvisit-fig figcaption b{font-weight:500;color:var(--n500,#5F7479)}@media (max-width:1000px){html .entry-content .sde-tx .txvisit{grid-template-columns:1fr;gap:28px}html .entry-content .sde-tx .txvisit-fig{order:-1}html .entry-content .sde-tx .txvisit-fig img{height:auto;min-height:0;flex:none;aspect-ratio:3\/2;object-position:50% 50%;border-radius:20px}html .entry-content .sde-tx .txvisit-fig--anim img{object-position:100% 50%;max-height:none}}<\/style>\n<div class=\"txvisit\">\n<ol class=\"txsteps\"><li><h3>Before<\/h3><p>Before treatment, the tear volume, tear film, ocular surface and lid margins are examined. Irrigation is also used to check that the tear ducts are <strong>fully patent<\/strong>. Adequate drainage is a prerequisite for the treatment. An active infection is treated first; inflamed lid margins should be sufficiently under control before occlusion.<\/p><\/li><li><h3>During<\/h3><p>The ocular surface is numbed with drops. If necessary, the punctum is gently dilated. The doctor then introduces the gel into the lower canaliculus with a fine lacrimal cannula. If both eyes are affected, both can be treated in the same session. Usually only slight pressure is felt; the treatment <strong>takes a few minutes<\/strong>.<\/p><\/li><li><h3>After<\/h3><p>Usual activities can generally be resumed straight away. After placement, a little gel may emerge at the upper punctum. If it affects vision, it is rinsed off the ocular surface. Contact the treatment centre if you have <strong>persistent watering, pain, increasing redness, swelling or discharge<\/strong>.<\/p><\/li><li><h3>Follow-up<\/h3><p>At the follow-up visit it is assessed whether symptoms and objective findings have improved. <strong>Early removal is possible<\/strong> and is required in the event of irritation, infection or persistent watering. Whether a repeat treatment makes sense later depends on the findings, the effect and how well it was tolerated.<\/p><\/li><\/ol>\n<figure class=\"txvisit-fig txvisit-fig--anim\"><img src=\"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-animacion-gel-canaliculo.webp\" alt=\"Rendered illustration of an eye: a fine cannula at the lower punctum, with the tear canals and the lacrimal sac highlighted in pink\" width=\"1920\" height=\"1080\" loading=\"lazy\" decoding=\"async\"><figcaption><b>The gel is introduced through the lower punctum into the tear canal. Illustration; the anatomy varies from patient to patient.<\/b><span style=\"display:block\">Image: <a href=\"https:\/\/lacrifill.co.uk\/administration\/\" rel=\"nofollow noopener\" target=\"_blank\">Nordic Pharma \u00b7 lacrifill.co.uk<\/a> (edited)<\/span><\/figcaption><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"txb txb--tint\">\n<div class=\"txw\">\n<div class=\"txhead\"><span class=\"txnum\">04<\/span><span class=\"txrule\"><\/span><\/div><h2 class=\"txh\" id=\"who-lacrifill-is-suitable-for\">Who Lacrifill is suitable for<\/h2>\n<div class=\"txtwo\"><div class=\"txcard txcard--yes\"><h3>Possible indications<\/h3><ul><li>Lacrifill\u00ae can be considered for adults with persistent symptoms of dry eye when these can be relieved by reducing the tear outflow.<\/li><li>Particularly relevant are a confirmed aqueous tear deficiency and findings of an insufficiently wetted ocular surface.<\/li><li>The procedure provides a temporary occlusion that is not visible from outside and can be considered when preformed plugs are not suitable or were not tolerated.<\/li><\/ul><\/div><div class=\"txcard txcard--no\"><h3>Contraindications and limits<\/h3><ul><li>Lacrifill\u00ae must not be used in the presence of an obstruction of the tear drainage, an active infection of the eye or its surroundings, inflammation of the ocular surface not caused by dry eye, or a known allergy to hyaluronic acid.<\/li><li>In ectropion, clinical performance has not been established.<\/li><li>Inflamed lid margins and meibomian gland dysfunction are generally treated, or brought under control, first.<\/li><li>Lacrifill\u00ae is intended for adults. Clinical performance has not been established, and use may not be advisable, during pregnancy and breastfeeding, in children and adolescents, within six months of eye surgery, and with several other pre-existing conditions and concomitant medications. These points are checked by the doctor before treatment.<\/li><li>In predominantly evaporative dry eye with a normal tear volume, Lacrifill\u00ae is not the primary treatment.<\/li><\/ul><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"txb\">\n<div class=\"txw\">\n<div class=\"txhead\"><span class=\"txnum\">05<\/span><span class=\"txrule\"><\/span><\/div><h2 class=\"txh\" id=\"what-it-costs\">Costs<\/h2>\n<div class=\"txprice txprice--1\">\n<div class=\"txpcard\"><p class=\"region\">Europe<\/p>\n<div class=\"txprow\"><p class=\"lbl\">Lacrifill\u00ae treatment, both eyes<\/p><p class=\"amt\">on request<\/p><\/div>\n<div class=\"txprow\"><p class=\"lbl\">Follow-up or return visit<\/p><p class=\"amt\">from \u20ac150<\/p><\/div>\n<\/div>\n<\/div>\n<p class=\"txpfoot\">The actual costs depend on the treatment centre, the extent of treatment and any combination therapies. Lacrifill\u00ae has been available in several European markets since 2026 and is not offered at every centre. In Germany, this is generally a private medical service. Whether a private health insurer or the Beihilfe scheme covers the costs depends on the individual policy and case. You will receive written cost information before treatment.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"txb txb--tint\">\n<div class=\"txw\">\n<div class=\"txhead\"><span class=\"txnum\">06<\/span><span class=\"txrule\"><\/span><\/div><h2 class=\"txh\" id=\"lacrifill-questions\">Frequently asked questions<\/h2>\n<div class=\"txfaq\"><details><summary>Is the treatment painful?<\/summary><div class=\"a\"><p>The ocular surface is numbed with drops beforehand. When the gel is introduced, usually only slight pressure is felt at the inner corner of the eye. Temporary irritation or a foreign-body sensation is possible afterwards.<\/p><\/div><\/details><details><summary>Can you feel or see the gel?<\/summary><div class=\"a\"><p>Usually not. The gel lies inside the canaliculus and is <strong>not visible from outside<\/strong>. Unlike a plug with a collar, nothing rests on the lid margin.<\/p><\/div><\/details><details><summary>How long does the effect last?<\/summary><div class=\"a\"><p>Lacrifill\u00ae is intended for use for <strong>up to six months<\/strong>. Safety and effectiveness beyond that period have not been established. How long the effect lasts in an individual case, and whether a repeat treatment makes sense later, depends on the findings and the course.<\/p><\/div><\/details><details><summary>Can the gel be removed again?<\/summary><div class=\"a\"><p>Yes. In the event of irritation, infection, persistent watering or another adverse event, the gel is rinsed out of the canaliculus with sterile saline. Whether further measures are needed is decided by the treating ophthalmologist.<\/p><\/div><\/details><details><summary>What side effects are possible?<\/summary><div class=\"a\"><p>Possible effects include a watery eye (epiphora), foreign-body sensation, itching, local irritation, swelling or pain at the lid. Less commonly, inflammation or infection of the tear ducts, allergic reactions, a granuloma or damage to the cornea can occur. In the event of irritation, infection or epiphora, the gel should be removed. Medicated eye drops may remain on the eye for longer; their dosage may therefore need to be adjusted.<\/p><\/div><\/details><details><summary>How does Lacrifill\u00ae differ from punctal plugs?<\/summary><div class=\"a\"><p>Both procedures reduce tear drainage. Punctal plugs are preformed and are chosen in a suitable size. Silicone plugs sit visibly in the punctum, can be felt as bothersome or fall out, and can usually be removed with forceps. Lacrifill\u00ae fills the canaliculus as a gel, needs no fixed size selection, is not visible from outside and <strong>can be removed by irrigation<\/strong>. It is intended for use for up to six months. Which method is suitable is decided by the medical examination.<\/p><\/div><\/details><details><summary>How well studied is Lacrifill\u00ae?<\/summary><div class=\"a\"><p>In a randomised, double-masked study at five US centres, 157 patients were treated. Lacrifill\u00ae was compared with an intracanalicular hydrogel plug. After three months the gel was <strong>non-inferior<\/strong> to the comparator in terms of tear volume and symptoms; the improvements observed persisted to month six. The study showed <strong>no superiority<\/strong>, included no sham treatment and provides no data beyond six months. TFOS DEWS III lists cross-linked hyaluronic acid gel as a tear conservation procedure. A treatment outcome cannot be guaranteed in the individual case.<\/p><\/div><\/details><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"txb\"><div class=\"txw\"><div class=\"txcta\"><h2>Which treatment is right for your eyes<\/h2><p>Dry eye can have different causes. Biofilm, inflamed lid margins, thickened meibum, ocular rosacea and aqueous tear deficiency each call for a different therapeutic approach. Smart Dry Eyes records the relevant findings systematically. On that basis, the ophthalmologist decides which treatment or combination is right for you.<\/p><div class=\"txbtns\"><a class=\"txp\" href=\"https:\/\/smartdryeyes.com\/en\/start-dry-eye-treatment\/\">Start your screening<\/a><a class=\"txo\" href=\"https:\/\/smartdryeyes.com\/en\/dry-eye-treatment-options\/\">All treatment options<\/a><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"txb txb--tint\"><div class=\"txw\"><h2 class=\"txh\">Other treatments for dry eyes<\/h2><div class=\"txrel\"><a class=\"txrelc\" href=\"https:\/\/smartdryeyes.com\/en\/punctal-plugs-for-dry-eyes\/\"><span class=\"t\">Punctal plugs<\/span><span class=\"g\">Closing the tear drainage with small plugs in the punctum<\/span><\/a><a class=\"txrelc\" href=\"https:\/\/smartdryeyes.com\/en\/eyelid-cleansing-blepharoexfoliation\/\"><span class=\"t\">Eyelid cleansing<\/span><span class=\"g\">Removing biofilm, crusts and deposits from the lid margin<\/span><\/a><a class=\"txrelc\" href=\"https:\/\/smartdryeyes.com\/en\/meibomian-gland-expression\/\"><span class=\"t\">Meibomian gland expression<\/span><span class=\"g\">Releasing warmed secretion from the glands in a controlled way<\/span><\/a><a class=\"txrelc\" href=\"https:\/\/smartdryeyes.com\/en\/tixel-treatment-for-dry-eyes\/\"><span class=\"t\">Tixel<\/span><span class=\"g\">Targeted heat treatment of the meibomian glands<\/span><\/a><a class=\"txrelc\" href=\"https:\/\/smartdryeyes.com\/en\/ipl-treatment-for-dry-eyes\/\"><span class=\"t\">IPL<\/span><span class=\"g\">Light-based therapy for inflammatory MGD and ocular rosacea<\/span><\/a><a class=\"txrelc\" href=\"https:\/\/smartdryeyes.com\/en\/low-level-light-therapy-for-dry-eyes\/\"><span class=\"t\">Low-level light therapy<\/span><span class=\"g\">Complementary photobiomodulation for selected inflammatory findings<\/span><\/a><a class=\"txrelc txrelc--hub\" href=\"https:\/\/smartdryeyes.com\/en\/dry-eye-treatment-options\/\"><span class=\"t\">Dry eye treatment options<\/span><span class=\"g\">All eight, compared<\/span><\/a><\/div><p class=\"txrev\">Medically reviewed by Dr. Ludger Hanneken, MD, PhD \u00b7 Medical Director, Smart Dry Eyes<\/p><\/div><\/div>\n\n\n\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"Is the treatment painful?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"The ocular surface is numbed with drops beforehand. When the gel is introduced, usually only slight pressure is felt at the inner corner of the eye. Temporary irritation or a foreign-body sensation is possible afterwards.\"}}, {\"@type\": \"Question\", \"name\": \"Can you feel or see the gel?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Usually not. The gel lies inside the canaliculus and is not visible from outside. Unlike a plug with a collar, nothing rests on the lid margin.\"}}, {\"@type\": \"Question\", \"name\": \"How long does the effect last?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Lacrifill\u00ae is intended for use for up to six months. Safety and effectiveness beyond that period have not been established. How long the effect lasts in an individual case, and whether a repeat treatment makes sense later, depends on the findings and the course.\"}}, {\"@type\": \"Question\", \"name\": \"Can the gel be removed again?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes. In the event of irritation, infection, persistent watering or another adverse event, the gel is rinsed out of the canaliculus with sterile saline. Whether further measures are needed is decided by the treating ophthalmologist.\"}}, {\"@type\": \"Question\", \"name\": \"What side effects are possible?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Possible effects include a watery eye (epiphora), foreign-body sensation, itching, local irritation, swelling or pain at the lid. Less commonly, inflammation or infection of the tear ducts, allergic reactions, a granuloma or damage to the cornea can occur. In the event of irritation, infection or epiphora, the gel should be removed. Medicated eye drops may remain on the eye for longer; their dosage may therefore need to be adjusted.\"}}, {\"@type\": \"Question\", \"name\": \"How does Lacrifill\u00ae differ from punctal plugs?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Both procedures reduce tear drainage. Punctal plugs are preformed and are chosen in a suitable size. Silicone plugs sit visibly in the punctum, can be felt as bothersome or fall out, and can usually be removed with forceps. Lacrifill\u00ae fills the canaliculus as a gel, needs no fixed size selection, is not visible from outside and can be removed by irrigation. It is intended for use for up to six months. Which method is suitable is decided by the medical examination.\"}}, {\"@type\": \"Question\", \"name\": \"How well studied is Lacrifill\u00ae?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"In a randomised, double-masked study at five US centres, 157 patients were treated. Lacrifill\u00ae was compared with an intracanalicular hydrogel plug. After three months the gel was non-inferior to the comparator in terms of tear volume and symptoms; the improvements observed persisted to month six. The study showed no superiority, included no sham treatment and provides no data beyond six months. TFOS DEWS III lists cross-linked hyaluronic acid gel as a tear conservation procedure. A treatment outcome cannot be guaranteed in the individual case.\"}}]}<\/script>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Treatment Lacrifill\u00ae Treatment for Dry Eyes Cross-linked hyaluronic acid gel for temporary closure of the tear drainage Lacrifill\u00ae is a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-6027","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lacrifill\u00ae Treatment for Dry Eyes | Smart Dry Eyes<\/title>\n<meta name=\"description\" content=\"Lacrifill\u00ae is a cross-linked hyaluronic acid gel that temporarily reduces tear drainage. When it is used, what the visit involves, who it suits, the evidence, risks and costs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lacrifill\u00ae Treatment for Dry Eyes | Smart Dry Eyes\" \/>\n<meta property=\"og:description\" content=\"Lacrifill\u00ae is a cross-linked hyaluronic acid gel that temporarily reduces tear drainage. When it is used, what the visit involves, who it suits, the evidence, risks and costs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/\" \/>\n<meta property=\"og:site_name\" content=\"Smart Dry Eyes\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/smartdryeyes\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-22T16:47:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-gel-hialuronico-hero.webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/lacrifill-treatment-for-dry-eyes\\\/\",\"url\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/lacrifill-treatment-for-dry-eyes\\\/\",\"name\":\"Lacrifill\u00ae Treatment for Dry Eyes | Smart Dry Eyes\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/lacrifill-treatment-for-dry-eyes\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/lacrifill-treatment-for-dry-eyes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/smartdryeyes.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/lacrifill-gel-hialuronico-hero.webp\",\"datePublished\":\"2026-09-22T15:41:19+00:00\",\"dateModified\":\"2026-09-22T16:47:05+00:00\",\"description\":\"Lacrifill\u00ae is a cross-linked hyaluronic acid gel that temporarily reduces tear drainage. When it is used, what the visit involves, who it suits, the evidence, risks and costs.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/lacrifill-treatment-for-dry-eyes\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/lacrifill-treatment-for-dry-eyes\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/lacrifill-treatment-for-dry-eyes\\\/#primaryimage\",\"url\":\"https:\\\/\\\/smartdryeyes.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/lacrifill-gel-hialuronico-hero.webp\",\"contentUrl\":\"https:\\\/\\\/smartdryeyes.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/lacrifill-gel-hialuronico-hero.webp\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/lacrifill-treatment-for-dry-eyes\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/home\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Lacrifill\u00ae Treatment for Dry Eyes\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/\",\"name\":\"Smart Dry Eyes\",\"description\":\"RB 2124:en\\\/tr879\\\/srcde 2125:es\\\/tr879\\\/srcde 2126:en\\\/tr878\\\/srcde 2127:es\\\/tr878\\\/srcde 2090:de\\\/tr879\\\/src- 2089:de\\\/tr878\\\/src-\",\"publisher\":{\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/#organization\",\"name\":\"Smart Dry Eyes\",\"url\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/smartdryeyes.com\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/cropped-sde-logo.webp\",\"contentUrl\":\"https:\\\/\\\/smartdryeyes.com\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/cropped-sde-logo.webp\",\"width\":264,\"height\":264,\"caption\":\"Smart Dry Eyes\"},\"image\":{\"@id\":\"https:\\\/\\\/smartdryeyes.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/smartdryeyes\",\"https:\\\/\\\/www.youtube.com\\\/@smartdryeyes\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/smartdryeyes\",\"https:\\\/\\\/www.instagram.com\\\/smartdryeyes\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Lacrifill\u00ae Treatment for Dry Eyes | Smart Dry Eyes","description":"Lacrifill\u00ae is a cross-linked hyaluronic acid gel that temporarily reduces tear drainage. When it is used, what the visit involves, who it suits, the evidence, risks and costs.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/","og_locale":"en_US","og_type":"article","og_title":"Lacrifill\u00ae Treatment for Dry Eyes | Smart Dry Eyes","og_description":"Lacrifill\u00ae is a cross-linked hyaluronic acid gel that temporarily reduces tear drainage. When it is used, what the visit involves, who it suits, the evidence, risks and costs.","og_url":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/","og_site_name":"Smart Dry Eyes","article_publisher":"https:\/\/www.facebook.com\/smartdryeyes","article_modified_time":"2026-09-22T16:47:05+00:00","og_image":[{"url":"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-gel-hialuronico-hero.webp","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"9 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/","url":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/","name":"Lacrifill\u00ae Treatment for Dry Eyes | Smart Dry Eyes","isPartOf":{"@id":"https:\/\/smartdryeyes.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/#primaryimage"},"image":{"@id":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/#primaryimage"},"thumbnailUrl":"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-gel-hialuronico-hero.webp","datePublished":"2026-09-22T15:41:19+00:00","dateModified":"2026-09-22T16:47:05+00:00","description":"Lacrifill\u00ae is a cross-linked hyaluronic acid gel that temporarily reduces tear drainage. When it is used, what the visit involves, who it suits, the evidence, risks and costs.","breadcrumb":{"@id":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/#primaryimage","url":"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-gel-hialuronico-hero.webp","contentUrl":"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2026\/09\/lacrifill-gel-hialuronico-hero.webp"},{"@type":"BreadcrumbList","@id":"https:\/\/smartdryeyes.com\/en\/lacrifill-treatment-for-dry-eyes\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/smartdryeyes.com\/en\/home\/"},{"@type":"ListItem","position":2,"name":"Lacrifill\u00ae Treatment for Dry Eyes"}]},{"@type":"WebSite","@id":"https:\/\/smartdryeyes.com\/en\/#website","url":"https:\/\/smartdryeyes.com\/en\/","name":"Smart Dry Eyes","description":"RB 2124:en\/tr879\/srcde 2125:es\/tr879\/srcde 2126:en\/tr878\/srcde 2127:es\/tr878\/srcde 2090:de\/tr879\/src- 2089:de\/tr878\/src-","publisher":{"@id":"https:\/\/smartdryeyes.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/smartdryeyes.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/smartdryeyes.com\/en\/#organization","name":"Smart Dry Eyes","url":"https:\/\/smartdryeyes.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/smartdryeyes.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2025\/10\/cropped-sde-logo.webp","contentUrl":"https:\/\/smartdryeyes.com\/wp-content\/uploads\/2025\/10\/cropped-sde-logo.webp","width":264,"height":264,"caption":"Smart Dry Eyes"},"image":{"@id":"https:\/\/smartdryeyes.com\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/smartdryeyes","https:\/\/www.youtube.com\/@smartdryeyes","https:\/\/www.linkedin.com\/company\/smartdryeyes","https:\/\/www.instagram.com\/smartdryeyes"]}]}},"_links":{"self":[{"href":"https:\/\/smartdryeyes.com\/en\/wp-json\/wp\/v2\/pages\/6027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/smartdryeyes.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/smartdryeyes.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/smartdryeyes.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/smartdryeyes.com\/en\/wp-json\/wp\/v2\/comments?post=6027"}],"version-history":[{"count":8,"href":"https:\/\/smartdryeyes.com\/en\/wp-json\/wp\/v2\/pages\/6027\/revisions"}],"predecessor-version":[{"id":6114,"href":"https:\/\/smartdryeyes.com\/en\/wp-json\/wp\/v2\/pages\/6027\/revisions\/6114"}],"wp:attachment":[{"href":"https:\/\/smartdryeyes.com\/en\/wp-json\/wp\/v2\/media?parent=6027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}